![]() Pennsylvania will allocate the Johnson & Johnson vaccine to public and private school teachers and staff, including bus drivers, to reopen schools as soon as possible. If supply of this vaccine increases, however, the city will consider expanding eligibility. Philadelphia officials have decided to dedicate the Johnson & Johnson vaccine for those who are “hard to reach.” That includes people who are homebound, people with limited mobility, and people experiencing homelessness. Will the Johnson & Johnson vaccine be targeted to any particular population? The FDA says efficacy “demonstrated in the clinical trial reflected protection against several emerging SARS-CoV-2 variants of concern, including the Wuhan-H1 variant D614G (predominant in the United States), the B.1.351 variant (predominant in South Africa), and a P.2 variant (predominant in Brazil).” The company has applied to British regulators for permission to distribute the vaccine there a variant known as B.1.1.7 is common in the United Kingdom. The Johnson & Johnson vaccine appears to protect against several variants of the virus. Wherry said that opens up possibilities for delivery to rural America, farther from major medical centers that have the necessary cold chain for the other vaccines. “You think about populations that are more transient that are harder to track.”īoth the Moderna and Pfizer vaccines require cold storage that makes delivery complicated, while Johnson & Johnson’s vaccine can be kept at normal refrigerated temperatures. “I think in terms of one shot versus two shots, you can start thinking about underserved communities where it may be harder to follow up and ask people to come back for second shots,” said John Wherry, director of the Institute for Immunology at the Perelman School of Medicine at the University of Pennsylvania. Because of that, health officials in some jurisdictions are considering offering the Johnson & Johnson vaccine to those who may be hard to reach or who are otherwise unlikely to get a second dose. Johnson & Johnson’s vaccine is effective after only one dose, while Moderna and Pfizer both require two. What else makes the Johnson & Johnson vaccine different? Vaccine recipients cannot catch COVID-19 or a cold from any of the vaccines because they do not contain live virus. Once the cells create the spike protein found on the coronavirus, the immune system responds, conferring protection if the person is exposed to the real virus. That DNA is encapsulated in an inactivated adenovirus - the virus that causes the common cold - that cannot replicate in the body. Johnson & Johnson’s vaccine also delivers the body a recipe for creating the spike protein, but it uses DNA instead of RNA. Moderna and Pfizer’s vaccines enclose their mRNA in lipid nanoparticles, for which manufacturing facilities have had trouble ramping up production, contributing to bogged-down supply chain issues. Those two use messenger RNA to direct the body to make the virus’ spike protein. unit, is created using similar, but slightly different technology than is used in making the Pfizer and Moderna vaccines. ![]() The vaccine, produced by Johnson & Johnson’s Janssen Pharmaceutical Cos. ![]() What’s in the vaccine, and how does it work? WHYY thanks our sponsors - become a WHYY sponsorīut ultimately the FDA and CDC decided that J&J’s one-and-done vaccine is critical to fight the pandemic - and that the small clot risk could be handled with warnings to help younger women decide if they should use that shot or an alternative. Three died, and seven remain hospitalized. The government uncovered 15 vaccine recipients who developed the highly unusual kind of blood clot, out of nearly 8 million people given the J&J shot. health officials lifted the pause after scientific advisers decided the vaccine’s benefits outweigh the risks. Th e FDA and the Centers for Disease Control and Prevention called April 13 for a pause in use, “in an abundance of caution,” after six women experienced a rare and severe type of blood clot after receiving the vaccine. This is one of a series of articles in which reporters from WHYY’s Health Desk Help Desk answer questions about vaccines and COVID-19 submitted by you, our audience.ĭoses of Johnson & Johnson’s coronavirus vaccine for people ages 18 and older was first authorized for emergency use by the Food and Drug Administration in late February. Ask us about COVID-19: What questions do you have about the coronavirus and vaccines? ![]()
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